Evolution from Proto-Life to Metabolic Networks: Difference between revisions
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== Idea == | == Idea == | ||
Given the concept of the Metabolism First Hypothesis, how did early simple and essentially random reaction networks evolve into ones that exhibit characteristics of scale-free and small-world (sf-sw) networks? What physically meaningful rules may we find that can lead to this? | Given the concept of the [http://en.wikipedia.org/wiki/Origin_of_life#.22Metabolism_first.22_models:_iron-sulfur_world_and_others Metabolism First Hypothesis], how did early simple and essentially random reaction networks evolve into ones that exhibit characteristics of scale-free and small-world (sf-sw) networks? What physically meaningful rules may we find that can lead to this? | ||
Revision as of 03:30, 8 June 2007
| CSSS Santa Fe 2007 |
People
(Just sign up yourself, if interested, or, whom I've just forgotten)
- Kathryn Cooper
- Amelie Veron
- Wenyun Zuo
- Christian Darabos
- Tim Johann
- Vikas Shah
- Joshua L. Payne
Idea
Given the concept of the Metabolism First Hypothesis, how did early simple and essentially random reaction networks evolve into ones that exhibit characteristics of scale-free and small-world (sf-sw) networks? What physically meaningful rules may we find that can lead to this?
Outline
...
Things to consider
- No predefined goal! Besides evolvability. I.e. we don't use a fitness function based on a known goal state.
- How to define fitness? Or, how to define selection without a known fitness function?
- How can we get increasing structural complexity of metabolites?
- Does structural complexity of metaboltes really imply a tendency to sf-sw?
Space for Opinions
It seemed at our first meeting, that everybody involved (but me) assumed I wanted to take the role of the leader. Actually, I wanted to have an open discussion about what WE want to achieve. -- Tim
As the group of interested people is so large and the number of opinions as well, we could split into two groups with different approaches or goals. With a meeting once or twice a week.
Readings
- nearly anything by Stuart Kauffman (I just borrowed 'The Origins of Order').
- Gunter Wachtershauser has painted a detailed picture of the chemical possibilities based on geothermal vents. He has a bunch of publications that pop up on Google scholar. Steen would definitely say he has painted himself into a corner, but he has some really interesting hypotheses.