Evolution from Proto-Life to Metabolic Networks: Difference between revisions
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== Idea == | == Idea == | ||
Given the concept of the Metabolism First Hypothesis, how did early simple and essentially random reaction networks evolve into ones that exhibit characteristics of scale-free and small-world networks? What physically meaningful rules may we find that can lead to this? | Given the concept of the Metabolism First Hypothesis, how did early simple and essentially random reaction networks evolve into ones that exhibit characteristics of scale-free and small-world (sf-sw) networks? What physically meaningful rules may we find that can lead to this? | ||
== Things to consider == | == Things to consider == | ||
* No predefined goal! Besides evolvability. | * No predefined goal! Besides evolvability. I.e. we don't use a fitness function based on a known goal state. | ||
* How to define fitness? Or, how to define selection without a known fitness function? | * How to define fitness? Or, how to define selection without a known fitness function? | ||
** Yes, I though it might be interesting to run simulations without fitness and selection, just based on the rules of evolution and see what comes out -- [http://www.santafe.edu/events/workshops/index.php/Amelie_Veron Amelie] | ** Yes, I though it might be interesting to run simulations without fitness and selection, just based on the rules of evolution and see what comes out -- [http://www.santafe.edu/events/workshops/index.php/Amelie_Veron Amelie] | ||
*** What to do about the explosion of possibilities? [[http://www.santafe.edu/events/workshops/index.php/Tim_Johann Tim]] | *** What to do about the explosion of possibilities? [[http://www.santafe.edu/events/workshops/index.php/Tim_Johann Tim]] | ||
* How can we get increasing structural complexity of metabolites? | * How can we get increasing structural complexity of metabolites? | ||
* Does structural complexity of metaboltes really imply a tendency to sf-sw? | |||
== Readings == | == Readings == | ||
* nearly anything by Stuart Kauffman (I just borrowed 'The Origins of Order'). | * nearly anything by Stuart Kauffman (I just borrowed 'The Origins of Order'). | ||
Revision as of 20:35, 7 June 2007
| CSSS Santa Fe 2007 |
First meeting scheduled for Thu, Jun 7, 10:15am after the lecture.
People
(Just sign up yourself, if interested, or, whom I've just forgotten)
- Kathryn Cooper
- Amelie Veron
- Wenyun Zuo
- Christian Darabos
- Tim Johann
- Vikas Shah
- Joshua L. Payne
Idea
Given the concept of the Metabolism First Hypothesis, how did early simple and essentially random reaction networks evolve into ones that exhibit characteristics of scale-free and small-world (sf-sw) networks? What physically meaningful rules may we find that can lead to this?
Things to consider
- No predefined goal! Besides evolvability. I.e. we don't use a fitness function based on a known goal state.
- How to define fitness? Or, how to define selection without a known fitness function?
- How can we get increasing structural complexity of metabolites?
- Does structural complexity of metaboltes really imply a tendency to sf-sw?
Readings
- nearly anything by Stuart Kauffman (I just borrowed 'The Origins of Order').