Cardiac arrhythmias in ion channel dysregulation: Difference between revisions
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{{CSSS 2007 Santa Fe}} | {{CSSS 2007 Santa Fe}} | ||
==Concept== | ==Concept== | ||
Hi everyone, this is a project related to modeling cardiac tissue with the aim of attempting to understand the conditions under which pathological arrhythmias are evoked. These would include ventricular fibrillation and/or torsades de pointes. I am specifically interested in examining the systemic effect of modulating myocyte function by altering specific ion channel parameters, though it would also be interesting to model the effects of myocardial infarction (dead/dying tissue in the heart due to heart attack). I'm open to other ideas as well. | |||
==Who's interested== (add your name!) | ==Who's interested== (add your name!) | ||
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==Questions to answer== | ==Questions to answer== | ||
* Can we create a minimal but useful model of cardiac tissue that appears to have normal function? | |||
* What are the effects of perturbing ionic concentrations? | |||
* What are the effects of perturbing ion channel functions? | |||
* What are the effects of perturbing topological characteristics of the model (e.g. "damaging" part of the "heart")? | |||
==Background reading== | ==Background reading== | ||
==Possibly related== | ==Possibly related== | ||
Revision as of 20:44, 5 June 2007
| CSSS Santa Fe 2007 |
Concept
Hi everyone, this is a project related to modeling cardiac tissue with the aim of attempting to understand the conditions under which pathological arrhythmias are evoked. These would include ventricular fibrillation and/or torsades de pointes. I am specifically interested in examining the systemic effect of modulating myocyte function by altering specific ion channel parameters, though it would also be interesting to model the effects of myocardial infarction (dead/dying tissue in the heart due to heart attack). I'm open to other ideas as well.
==Who's interested== (add your name!)
- Vikas Shah
Questions to answer
- Can we create a minimal but useful model of cardiac tissue that appears to have normal function?
- What are the effects of perturbing ionic concentrations?
- What are the effects of perturbing ion channel functions?
- What are the effects of perturbing topological characteristics of the model (e.g. "damaging" part of the "heart")?