Scaling in Biological and Social Networks - Abstract - Lesne
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Transcriptional regulatory networks and the chromatin fiber
Annick Lesne (IHÉS & LPTMC Paris 6)
Multi-scale modeling is essential to unravel the complex interplay between the chromatin fiber architecture and functional organization. and the DNA levels. It suggests that a major role of the chromatin fiber architecture might be to impose mechanical and topological constraints at the DNA level, endowing local stretches of DNA with allosteric potentialities. The epigenetic tuning of chromatin architecture, e.g. through histone post-translational modifications, thus offers a way to control DNA transactions and thereby transcription regulation. Chromatin fiber functional structure and dynamics is thus an essential substrate of gene regulatory networks, and these two approaches have to be bridge in order to reach a full understanding of transcription and analyze transcriptomic data.
(Joint work with Jean-Marc Victor, LPTMC Paris 6, and Arndt Benecke, IHÉS)