HP Modularity: Difference between revisions
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=== ''Major'' Questions === | === ''Major'' Questions === | ||
#Does modularity in pathogen ''genes'' responsible for an interaction with a host increase its ability to adapt to a host? | #Does modularity in pathogen ''genes'' responsible for an interaction with a host increase its ability to adapt to a host? | ||
# Is modularity in the host required for pathogen modularity to arise/emerge? | |||
#additional ones here | #additional ones here | ||
=== Model Details === | === Model Details === | ||
==== Discrete or continuous? ==== | |||
# Pros for discrete: easier to run iterated simulations; possible to run experiments on explicit graph structures | |||
# Pros for continuous: mathematical derivations cleaner | |||
== Glossary == | |||
=== Modularity Concepts === | |||
I'm quite sure that there is some overloading here; but these are the types of modularity that have come up in our discussions: | |||
# Modularity for reassortment (Molly) | |||
# Modularity for independence (Molly) (I call this 'functional decomposition' - Rob) | |||
# Repeated modularity: eg where a body segment occurs many times in an organism (Rob) | |||
# Modularity for robustness to antagonistic pleiotrophy (Molly) | |||
=== Pathogen-related terms === | |||
# '''Epitope ''': the phenotype of a pathogen that interacts with a host | |||
## only need to consider a portion of the host's genome since the pathogen only targets a specialised portion of that genome. | |||
Revision as of 04:59, 12 June 2008
Host-Pathogen Modularity
This is the working space for our project. Everything written is a work in progress.
Title Ideas
- Evolution of modularity in a host-pathogen system
- Modularity: a pathogen's answer to host interactions
- more here
Major Questions
- Does modularity in pathogen genes responsible for an interaction with a host increase its ability to adapt to a host?
- Is modularity in the host required for pathogen modularity to arise/emerge?
- additional ones here
Model Details
Discrete or continuous?
- Pros for discrete: easier to run iterated simulations; possible to run experiments on explicit graph structures
- Pros for continuous: mathematical derivations cleaner
Glossary
Modularity Concepts
I'm quite sure that there is some overloading here; but these are the types of modularity that have come up in our discussions:
- Modularity for reassortment (Molly)
- Modularity for independence (Molly) (I call this 'functional decomposition' - Rob)
- Repeated modularity: eg where a body segment occurs many times in an organism (Rob)
- Modularity for robustness to antagonistic pleiotrophy (Molly)
- Epitope : the phenotype of a pathogen that interacts with a host
- only need to consider a portion of the host's genome since the pathogen only targets a specialised portion of that genome.