Coupling of different types of networks

Logistics

Members

Sanja Selakovic (sanjakojasanja@gmail.com) :
Fahad Khalid (fahad.khalid@hpi.de)  :
Nhat (nhattdnguyen@gmail.com):
Beth Lusczek (lusc0006@umn.edu) :
Hiroshi (hashika1@jhmi.edu) :
Brian Thompson (bthompso8784@gmail.com)

Meetings

(1) Monday, June 16, 2014 - Agenda: - discussion of ideas for the model and system

(2) Tuesday, June 17, 2014

Files

Resuscitation Algorithm File:SupplFigure1 ResusAlg.pdf
Experimental Timeline File:Timeline.pdf

Datasets

http://snap.stanford.edu/data/#socnets

Literature

http://www.nature.com/nature/journal/v499/n7459/full/nature12277.html
http://arxiv.org/pdf/1012.0206.pdf
http://pidancer.com/research/dissertation_BrianThompson.pdf - Section 6.2 on Innovation and Circulation (pgs. 89-91)

Ideas

Look at coupling of metabolic networks in different physiologic compartments in a pig model of hemorrhagic shock.

Compartments are liver, muscle, urine, and serum. We have concentrations of approximately 50 metabolites in each compartment. There are about 10 metabolites that are common to all four compartments. We have profiled metabolites in each compartment at 5 different timepoints: Baseline (after instrumentation of the animal for experimentation) Shock (after 45 minutes of prolonged blood withdrawal, pulmonary contusion, and liver crush injury FR2 (after two hours of full resuscitation) FR8 (after eight hours of full resuscitation) FR20 (after 20 hours of full resuscitation)

There is one hour of limited resuscitation and one hour of full resuscitation between the Shock and FR2 timepoints. Limited resuscitation involves only giving fluid to a systolic blood pressure of 80 mmHg. Full resuscitation is done by algorithm. Figures illustrating the experimental timeline and full resuscitation strategies are posted to the page.