CSSS 2008 Santa Fe-Projects & Working Groups
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Antagonistic interspecific interactions
After chatting with several people about host-parasite systems and hearing some of the comments at the icebreaker, I want to see if others are interested in potential projects in this area. As a way of getting some brain storming started, I’ve just typed up some topics (these include ideas I’ve heard from others here at Santa Fe) to see if there is critical mass and an interesting question.
Topics (no particular order)
- Impact of immune system on host-parasite (/pathogen) interaction
- Impact of heterogeneous hosts
- Infectious diseases: epidemic outbreaks vs. endemic steady states
- Direct vs. vector transmission of parasites/pathogens
- Non-genetic transmission of disease resistance
- Effects of pathogen competition on epidemic outbreaks
- Spatial heterogeneity of transmission of parasites
Interested? Please add ideas that you find interesting or would like to explore more (or just your name).
Biological Levels / Phenotypes Discussion
We have a number of folks here either interested in or studying biology at various levels. I am interested in talking about ways in which it makes sense integrate different levels of biological knowledge into a representation of a system. For example, how might microRNA predictions be combined with gene expression networks (or proteomics or SNPs) to lead to a phenotype.
I am also interested in questions of how phenotypes are defined. Within an organ state (e.g., disease or not) for example, a phenotype might be defined as a gene expression pattern, a growth rate, a panel of microsatellite lengths, or functionally by in vivo or ex vivo capabilities to self-renew, etc. If what we are trying to understand is a larger question of disease or functionality, which phenotypes are interesting and useful (and possible!) to use?
I think these questions can be approached from a variety of ways. Off the top of my head, perhaps multi-scaled modeling or examining the system as a multi-level evolutionary system... I'm sure there are many others.
If you are interested, add your name and we can set up a time / place to talk about these and related questions.
Something in Neuroscience
I (Nish) would really like to do some more intensive, deep research in Neuroscience (Computational being my perspective). While I am fascinated by neurological and behavioral diseases, I would be open to any kind of neuroscientific problem. Anyone else?