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| '''Contact''': Hiroshi (hashika1@jhmi.edu)<br> | | '''Contact''': Hiroshi (hashika1@jhmi.edu)<br> |
| Thank you for your interest in our project. Please join us any time and share your thoughts!<br> | | Thank you for your interest in the project. Feel free to join us any time and share your thoughts!<br> |
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| '''06/12/2014 Brainstorming Session'''<br>
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| ''Why'': To identify adaptive mechanisms leading to cardiac arrhythmia in diseased hearts. Then localize the origin of arrhythmia (= wavebreak) and treat it before it happens.<br>
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| ''Hypothesis'': Arrhythmias result from an adaptive mechanism to optimize information transmission in abnormal hearts.<br>
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| ''Challenge'': Wavebreaks can occur in normal heart tissue.<br>
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| ''How'': Time series from a cellular automata model of the 2-D heart tissue. ?Time series of invasive electrogram from animal or human<br>
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| ''What'': To quantify information transmission within the heart<br>
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| Potential Metrics<br>
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| Mutual information - Calculate mutual information of two separate locations from binary time series (0–resting, 1–excited). A high mutual information suggests electrical coupling.<br>
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| Permutation Entropy - Temporal uncertainty<br>
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| Transfer Entropy - Spatial uncertainty<br>
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| '''06/13/2014 Unofficial Brainstorming Session'''<br>
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| Thank you all for suggesting useful reference articles. Here is the list:
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| 1. Cao ''et al''., Detecting Dynamical Changes in Time Series Using the Permutation Entropy. ''Phys Rev E Stat Nonlin Soft Matter Phys'' 70: 046217, 2004 [[File: 2004_CaoY_PRE.pdf]]<br>
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| 2. Rosso ''et al''., Distinguishing Noise from Chaos. ''Phys Rev Lett'' 99: 154102, 2007 [[File: 2007_RossoOA_PRL.pdf]]<br>
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| 3. Lacasa ''et al''., From Time Series to Complex Networks: The Visibility Graph. ''PNAS'' 105: 4972, 2008 [[File: 2008_LacasaL_PNAS.pdf]]<br>
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| 4. Lizier ''et al''., Local Information Transfer as a Spatiotemporal Filter for Complex Systems. ''Phys Rev E Stat Nonlin Soft Matter Phys'' 77: 026110, 2008 [[File: 2008_LizierJT_PRL.pdf]]<br>
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| 5. Cheong ''et al''., Information Transduction Capacity of Noisy Biochemical Signaling Networks. ''Science'' 334: 354, 2011 [[File:2011_Cheong_Science.pdf]]<br>
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| Let's read the reference papers above this weekend and discuss what exactly we should measure at the next meeting. The next meeting will be at 02:30pm on Monday 06/16/2014 (after my [tutorial]) in the lecture hall. If you have any questions I will be around this weekend. You will most certainly find me
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