May 20 Notes: Difference between revisions
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'''Changing the Paradigm''' | '''Changing the Paradigm''' | ||
* Current shortcomings of science as a whole | * Current shortcomings of biological science as a whole | ||
** | |||
** What are the most persuasive types of argument in biology? | |||
*** 1) controlled experiments | |||
*** 2) randomized controlled trials | |||
**** associative | |||
**** data mining | |||
*** 3) theory (limited) | |||
**** descriptive model | |||
**** predictive model | |||
**** mathematical analysis | |||
**** computation | |||
*** 4) simulation (emergence?) | |||
*** 5) case studies | |||
*** 6) expert opinion | |||
** Meta-issues | ** Meta-issues | ||
*** Language | *** Language | ||
| Line 29: | Line 43: | ||
* Spreading the word | * Spreading the word | ||
** creating big conference (like | ** creating big conference (like [http://www.mfoundation.org/UABBA/agenda/ Understanding Aging] and [http://www.singinst.org/media/singularitysummit2007 Singularity Summit]) | ||
** creating visual and video "body of literature" | ** creating visual and video "body of literature" | ||
** popular magazines (Wired, New Yorker, Harpers) | ** popular magazines (Wired, New Yorker, Harpers) | ||
| Line 53: | Line 67: | ||
** Help NCI clear the hurdles | ** Help NCI clear the hurdles | ||
*** [[http://www.cancer.gov/trwg/TRWG-definition-and-TR-continuum NCI Translational Continuum]] ([[http://www.cancer.gov/aboutnci/trwg/Pathways-to-Clinical-Goals Pathways to clinical goals)]] | *** [[http://www.cancer.gov/trwg/TRWG-definition-and-TR-continuum NCI Translational Continuum]] ([[http://www.cancer.gov/aboutnci/trwg/Pathways-to-Clinical-Goals Pathways to clinical goals)]] | ||
*** key is to get success stories | |||
** work with each other (and other friendlies) to yield success in somatic evolution validation | |||
*** common lexicon | |||
** stake claim on wikipedia | |||
** maverick funders and self-funders | ** maverick funders and self-funders | ||
*** 23andMe | *** Google, Hughes Institute, many others | ||
** partner/collaborate with personal genomics companies | |||
*** 23andMe, and others | |||
** creating financial incentives | ** creating financial incentives | ||
*** prize models | *** prize models | ||
Latest revision as of 21:09, 29 May 2008
Changing the Paradigm
- Current shortcomings of biological science as a whole
- What are the most persuasive types of argument in biology?
- 1) controlled experiments
- 2) randomized controlled trials
- associative
- data mining
- 3) theory (limited)
- descriptive model
- predictive model
- mathematical analysis
- computation
- 4) simulation (emergence?)
- 5) case studies
- 6) expert opinion
- What are the most persuasive types of argument in biology?
- Meta-issues
- Language
- lack of good and shared LEXICON slows understanding and progress:
- what is a "gene"?
- "genome" vs "chromosome"
- is it "noise", "randomness", "heterogeneity", "diversity"?
- METAPHORS affect what actions are taken and what systems are developed
- "war on cancer" leads to "military industrial complex" for cancer
- POLITICAL CORRECTNESS stiffles progress
- the "e" word
- PARADIGMS proscribe and limit what futures are possible
- treatment of disease vs. promotion of health
- taking evolution seriously means looking at the context that evolved for protection and promotion of cancer
- treatment of disease vs. promotion of health
- lack of good and shared LEXICON slows understanding and progress:
- Technology effects
- hammers & nails
- diff between engineered systems and evolved systems
- parodies belie truth: "how biologists learn to fix a radio"; "frog legs"
- scientists are especially susceptible
- speed of technological change
- Financial & political factors
- Fadism (technological, ideological, novelty)
- Pipeline effects
- Healthcare-industrial-governmental complex
- Difficulty in matching funding to specific people, groups, ideas
- Language
- Meta-issues
- Spreading the word
- creating big conference (like Understanding Aging and Singularity Summit)
- creating visual and video "body of literature"
- popular magazines (Wired, New Yorker, Harpers)
- newspapers
- conceptual pieces in traditional journals
- internet / web
- cancer complexity wiki merge with SFI wiki?
- individual blogging
- create new online journal
- "big ideas" conferences ([TED], PopTech, and others)
- popular book (ala Tipping Point, Freakonomics, et al)
- public speaking tour
- documentary (ala Inconveniet Truth)
- undergraduate education
- Nowak's program
- textbook specifically for undergrad
- courses surrounding textbook
- Ideas for catalyzing change
- alternative research institute
- piggyback on SFI, Wistar or other existing
- raise funds privately to start new one
- Help NCI clear the hurdles
- [NCI Translational Continuum] ([Pathways to clinical goals)]
- key is to get success stories
- work with each other (and other friendlies) to yield success in somatic evolution validation
- common lexicon
- stake claim on wikipedia
- maverick funders and self-funders
- Google, Hughes Institute, many others
- partner/collaborate with personal genomics companies
- 23andMe, and others
- creating financial incentives
- prize models
- peer review --> decision markets
- alternative research institute
- Lessons from other paradigm shifts
- what are closest examples?
- how the existing paradigm reacts to attack
- working within the system vs. outside and on the margins
- providing a better alternative (or hope thereof) is important
- Who's missing from this forum?