Signal transduction using real proteins: Difference between revisions
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:Cells use networks of interacting proteins to maintain homeostasis, orchestrate developmental processes, and adapt to environmental changes. A primary mechanism of signal transduction in cellular networks is allostery, in which molecular interactions influence protein activity through changes in protein structure. In traditional models of allostery, proteins adopt a limited number of well-defined conformations. However, real proteins fluctuate in thermal equilibrium, dynamically exploring microstates with diverse activity. | :Cells use networks of interacting proteins to maintain homeostasis, orchestrate developmental processes, and adapt to environmental changes. A primary mechanism of signal transduction in cellular networks is allostery, in which molecular interactions influence protein activity through changes in protein structure. In traditional models of allostery, proteins adopt a limited number of well-defined conformations. However, real proteins fluctuate in thermal equilibrium, dynamically exploring microstates with diverse activity. | ||
:In this talk I will examine the role of protein fluctuations in molecular interactions and allostery. Along the way I will describe recent insights into the induced fit vs. pre-existing equlibrium perspectives on binding and the evolution of protein functional sites. Finally, I will discuss some aspects of how protein fluctuations influence elementary steps in cellular signal transduction. | :In this talk I will examine the role of protein fluctuations in molecular interactions and allostery. Along the way I will describe recent insights into the induced fit vs. pre-existing equlibrium perspectives on binding and the evolution of protein functional sites. Finally, I will discuss some aspects of how protein fluctuations influence elementary steps in cellular signal transduction. | ||
Back to [[Principles of Biological Computation - Agenda | Agenda]]. | Back to [[Principles of Biological Computation - Agenda | Agenda]]. | ||
Latest revision as of 14:08, 10 May 2008
By Michael Wall, LANL.
- Cells use networks of interacting proteins to maintain homeostasis, orchestrate developmental processes, and adapt to environmental changes. A primary mechanism of signal transduction in cellular networks is allostery, in which molecular interactions influence protein activity through changes in protein structure. In traditional models of allostery, proteins adopt a limited number of well-defined conformations. However, real proteins fluctuate in thermal equilibrium, dynamically exploring microstates with diverse activity.
- In this talk I will examine the role of protein fluctuations in molecular interactions and allostery. Along the way I will describe recent insights into the induced fit vs. pre-existing equlibrium perspectives on binding and the evolution of protein functional sites. Finally, I will discuss some aspects of how protein fluctuations influence elementary steps in cellular signal transduction.
Back to Agenda.