Jessica Mar - Revision history

Jessicamar at 01:13, 24 June 2006

2006-06-24T01:13:05Z

← Older revision		Revision as of 01:13, 24 June 2006
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	''3. Do you have any projects or research interests that would benefit from an interdisciplinary approach?''		''3. Do you have any projects or research interests that would benefit from an interdisciplinary approach?''

	Calling all quantum physicists, and experts on statistical mechanics and thermodynamics! I would welcome long discussions with people who have had this kind of training as I am currently thinking about modeling the energy paths and landscapes that single cells ~~transverse~~ in transforming from one cellular state to another. This has potential applications to understanding how diseases progress, particularly cancer. One theory on how tumors are born (tumorigenesis) is based on the idea that a single normally healthy cell is triggered by some unknown event (sometimes a carcinogen), and morphs into a cancerous cell. This then disrupts this cell’s ability to communicate with neighboring cells and the end result is a tumor.		Calling all quantum physicists, and experts on statistical mechanics and thermodynamics! I would welcome long discussions with people who have had this kind of training as I am currently thinking about modeling the energy paths and landscapes that single cells traverse in transforming from one cellular state to another. This has potential applications to understanding how diseases progress, particularly cancer. One theory on how tumors are born (tumorigenesis) is based on the idea that a single normally healthy cell is triggered by some unknown event (sometimes a carcinogen), and morphs into a cancerous cell. This then disrupts this cell’s ability to communicate with neighboring cells and the end result is a tumor.

	''4. Do you have any ideas for what sort of project you would like to do this summer?''		''4. Do you have any ideas for what sort of project you would like to do this summer?''

Jessicamar at 01:03, 24 June 2006

2006-06-24T01:03:58Z

← Older revision		Revision as of 01:03, 24 June 2006
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	''4. Do you have any ideas for what sort of project you would like to do this summer?''		''4. Do you have any ideas for what sort of project you would like to do this summer?''

	Modeling intra-cellular dynamics (in English: trying to capture biological processes using complex systems). If we can come up with an adequate model, then we can make predictions about how biological processes will respond under different conditions (such as molecular perturbations, noise) and over periods of time..		Modeling intra-cellular dynamics (in English: trying to capture biological processes using complex systems). If we can come up with an adequate model, then we can make predictions about how biological processes will respond under different conditions (such as molecular perturbations, noise) and over periods of time.

	''5. Suppose you could travel one-hundred years in the future and ask researchers any three questions. What would those questions be?''		''5. Suppose you could travel one-hundred years in the future and ask researchers any three questions. What would those questions be?''

	What’s the molecular strategy behind your most effective virus vaccine?		What’s the molecular strategy behind your most effective virus vaccine?

	Do we understand yet (if at all), how stochastic noise in gene expression contributes to disease progression?		Do we understand yet (if at all), how stochastic noise in gene expression contributes to disease progression?
	Did insights arising from modeling cancer as a complex system eventually influence patient treatment regimes and drug discovery? (I guess that's really 2 questions...) :-)
			Did insights arising from modeling cancer as a complex system eventually influence patient treatment regimes and drug discovery and result in a more positive outcome for the patient? (I guess that's really 2 questions...) :-)

Jessicamar at 01:01, 24 June 2006

2006-06-24T01:01:07Z

Jessicamar at 01:00, 24 June 2006

2006-06-24T01:00:14Z

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 G'day! I'm Jess from Harvard University in Boston, USA. I'm doing my PhD at the Biostatistics Department (starting Year 4 in the Fall), and I do research in genomics and systems biology. I'm based at the Dana-Farber Cancer Institute. At unequal stages of maturation, my research interests include: molecular evolution of viruses, statistical computing, molecular phylogenetics, gene expression microarrays, microRNA and studying stochastic influences in molecular biology. I love traveling, running and I am looking forward to meeting you all soon! :-)
-[[Image:IMG 0419.JPG]]
+[[Image:IMG 0419-1.JPG]]
 Here's a pic of me and my "little" bro! :-)

Jessicamar at 00:54, 24 June 2006

2006-06-24T00:54:21Z

← Older revision		Revision as of 00:54, 24 June 2006
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	G'day! I'm Jess from Harvard University in Boston, USA. I'm doing my PhD at the Biostatistics Department (starting Year 4 in the Fall), and I do research in genomics and systems biology. I'm based at the Dana-Farber Cancer Institute. At unequal stages of maturation, my research interests include: molecular evolution of viruses, statistical computing, molecular phylogenetics, gene expression microarrays, microRNA and studying stochastic influences in molecular biology. I love traveling, running and ~~Chinese food!~~ I am looking forward to meeting you all soon! :-)		G'day! I'm Jess from Harvard University in Boston, USA. I'm doing my PhD at the Biostatistics Department (starting Year 4 in the Fall), and I do research in genomics and systems biology. I'm based at the Dana-Farber Cancer Institute. At unequal stages of maturation, my research interests include: molecular evolution of viruses, statistical computing, molecular phylogenetics, gene expression microarrays, microRNA and studying stochastic influences in molecular biology. I love traveling, running and I am looking forward to meeting you all soon! :-)

	[[Image:IMG 0419.JPG]]		[[Image:IMG 0419.JPG]]

	Here's a pic of me and my "little" bro! :-)		Here's a pic of me and my "little" bro! :-)

Jessicamar at 00:52, 24 June 2006

2006-06-24T00:52:49Z

← Older revision		Revision as of 00:52, 24 June 2006
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	G'day! I'm Jess from Harvard University in Boston, USA. I'm doing my PhD at the Biostatistics Department (starting Year 4 in the Fall), and I do research in genomics and systems biology. I'm based at the Dana-Farber Cancer Institute. At unequal stages of maturation, my research interests include: molecular evolution of viruses, statistical computing, molecular phylogenetics, gene expression microarrays, microRNA and studying stochastic influences in molecular biology. I love traveling, running and Chinese food! I am looking forward to meeting you all soon! :-)		G'day! I'm Jess from Harvard University in Boston, USA. I'm doing my PhD at the Biostatistics Department (starting Year 4 in the Fall), and I do research in genomics and systems biology. I'm based at the Dana-Farber Cancer Institute. At unequal stages of maturation, my research interests include: molecular evolution of viruses, statistical computing, molecular phylogenetics, gene expression microarrays, microRNA and studying stochastic influences in molecular biology. I love traveling, running and Chinese food! I am looking forward to meeting you all soon! :-)

			[[Image:IMG 0419.JPG]]

			Here's a pic of me and my "little" bro! :-)

Jessicamar at 00:42, 24 June 2006

2006-06-24T00:42:41Z

New page

G'day! I'm Jess from Harvard University in Boston, USA. I'm doing my PhD at the Biostatistics Department (starting Year 4 in the Fall), and I do research in genomics and systems biology. I'm based at the Dana-Farber Cancer Institute. At unequal stages of maturation, my research interests include: molecular evolution of viruses, statistical computing, molecular phylogenetics, gene expression microarrays, microRNA and studying stochastic influences in molecular biology. I love traveling, running and Chinese food! I am looking forward to meeting you all soon! :-)

← Older revision		Revision as of 01:01, 24 June 2006
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	Here's a pic of me and my "little" bro! :-)		Here's a pic of me and my "little" bro! :-)


	My 5 answers are listed here -		My 5 answers are listed here -

	''1. What topics do you have some expertise in and would you be willing to help others learn them?''		''1. What topics do you have some expertise in and would you be willing to help others learn them?''

	My research experience is in genomics. I would be very happy to give a broad overview of genomics if other people would like to learn about it. I could also give talks on gene expression microarrays, why and how these experiments have captured the attention of the molecular biology world and the statistical aspects that arise in analyzing this kind of data. And finally, if anyone wants to learn about the statistical programming language R, and how to do neat things with it, I am keen to give a talk about this too.		My research experience is in genomics. I would be very happy to give a broad overview of genomics if other people would like to learn about it. I could also give talks on gene expression microarrays, why and how these experiments have captured the attention of the molecular biology world and the statistical aspects that arise in analyzing this kind of data. And finally, if anyone wants to learn about the statistical programming language R, and how to do neat things with it, I am keen to give a talk about this too.

	''2. What do you want to learn at the CSSS?''		''2. What do you want to learn at the CSSS?''

	My primary interest is in modeling a single cell as a complex system. There are many different types of genomic data that one can use to construct a complex system. For this system, I have a lot of questions I want to ask of it, and from the CSSS I would love to learn most how to extract scientifically sound answers to these questions. For instance, how do complex systems respond to noise and perturbations? Can I model how a complex system behaves over time?		My primary interest is in modeling a single cell as a complex system. There are many different types of genomic data that one can use to construct a complex system. For this system, I have a lot of questions I want to ask of it, and from the CSSS I would love to learn most how to extract scientifically sound answers to these questions. For instance, how do complex systems respond to noise and perturbations? Can I model how a complex system behaves over time?

	''3. Do you have any projects or research interests that would benefit from an interdisciplinary approach?''		''3. Do you have any projects or research interests that would benefit from an interdisciplinary approach?''

	Calling all quantum physicists, and experts on statistical mechanics and thermodynamics! I would welcome long discussions with people who have had this kind of training as I am currently thinking about modeling the energy paths and landscapes that single cells transverse in transforming from one cellular state to another. This has potential applications to understanding how diseases progress, particularly cancer. One theory on how tumors are born (tumorigenesis) is based on the idea that a single normally healthy cell is triggered by some unknown event (sometimes a carcinogen), and morphs into a cancerous cell. This then disrupts this cell’s ability to communicate with neighboring cells and the end result is a tumor.		Calling all quantum physicists, and experts on statistical mechanics and thermodynamics! I would welcome long discussions with people who have had this kind of training as I am currently thinking about modeling the energy paths and landscapes that single cells transverse in transforming from one cellular state to another. This has potential applications to understanding how diseases progress, particularly cancer. One theory on how tumors are born (tumorigenesis) is based on the idea that a single normally healthy cell is triggered by some unknown event (sometimes a carcinogen), and morphs into a cancerous cell. This then disrupts this cell’s ability to communicate with neighboring cells and the end result is a tumor.

	''4. Do you have any ideas for what sort of project you would like to do this summer?''		''4. Do you have any ideas for what sort of project you would like to do this summer?''

	Modeling intra-cellular dynamics (in English: trying to capture biological processes using complex systems). If we can come up with an adequate model, then we can make predictions about how biological processes will respond under different conditions (such as molecular perturbations, noise) and over periods of time..		Modeling intra-cellular dynamics (in English: trying to capture biological processes using complex systems). If we can come up with an adequate model, then we can make predictions about how biological processes will respond under different conditions (such as molecular perturbations, noise) and over periods of time..

	''5. Suppose you could travel one-hundred years in the future and ask researchers any three questions. What would those questions be?''		''5. Suppose you could travel one-hundred years in the future and ask researchers any three questions. What would those questions be?''

	What’s the molecular strategy behind your most effective virus vaccine?		What’s the molecular strategy behind your most effective virus vaccine?
	Do we understand yet (if at all), how stochastic noise in gene expression contributes to disease progression?		Do we understand yet (if at all), how stochastic noise in gene expression contributes to disease progression?
	Did insights arising from modeling cancer as a complex system eventually influence patient treatment regimes and drug discovery? (I guess that's really 2 questions...) :-)		Did insights arising from modeling cancer as a complex system eventually influence patient treatment regimes and drug discovery? (I guess that's really 2 questions...) :-)