Age related decline, genetics and chance in a simple animal model: Do you need to be lucky to age well?
From Santa Fe Institute Events Wiki
Diverse species exhibit striking similarities in genetic and environmental factors that impact aging, despite considerable differences in overall lifespan and life histories. I will focus on current understanding of genetics and chance events in C. elegans aging. C. elegans is a genetically-amenable transparent 959-celled roundworm of fully known cellular developmental plan that lives for about 3 weeks. More than 200 genetic manipulations are known that can extend C. elegans lifespan. Different tissues decline at different rates as the animal ages, and it is clear that stochastic events can have a huge impact on the quality or rate of aging. I will suggest that recently discovered translational regulators microRNAs may normally ensure robustness in a biological system and suggest that changes in their abundance at mid-life might play a significant role in aging biology.